Mechanism of Antitumor Antibiotics Anthracycline Clinical Uses Adverse Effects

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#pharmacology #anticancerdrugs #anthracycline #doxorubicin #daunorubicin • Anthracycline • Anthracyclines are a class of drugs used in cancer chemotherapy that are extracted from Streptomyces bacterium. These compounds are used to treat many cancers, including leukemias, lymphomas, breast, stomach, uterine, ovarian, bladder cancer, and lung cancers. • Doxorubicin • Daunorubicin • Idarubicin • Epirubicin • Mitoxantrone • MECHANISM OF ACTION • Anthracyclines disrupt DNA by poisoning topoisomerase, a critical enzyme for unwinding of the DNA for replication and synthesis, thereby causing growth arrest and programmed cell death [15]. Cellular oxidative stress activates an array of kinase pathways that modulate myocyte fate and response to anthracyclines. • ADVERSE EFFECTS • Cardiotoxicity • BM Suppression • Nausea • Vomiting • Diarrhea • Alopecia • GIT distress • #doxorubicin • #daunorubicin

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