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Robinson annulation
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=i0G5odZBs1g
directory of Chem Help ASAP videos: https://www.chemhelpasap.com/youtube/ • The Robinson annulation is a combination of two reactions. The Robinson starts with a Michael addition. It finishes with an intramolecular aldol condensation to form a cyclic alpha,beta-unsaturated ketone. The reaction occurs in base to form a Michael donor from a 1,3-dicarbonyl compound. The product of the Michael addition forms a ketone with an alpha-carbon that is six atoms away from an electrophilic carbon. Formation of an enolate, attack on the carbonyl, and loss of water gives the unsaturated ketone. The Robinson is sensitive reaction, and rarely gives a high yield. Two well-known Robinson products are the Wieland-Miescher ketone and the Hajos-Parrish ketone, both of which can be used to make steriods.
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