Panel IV Discussion of HPAI H5N1 GOF Research Case Studies

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Gain-of-Function Research on Highly Pathogenic Avian Influenza H5N1 Viruses: • An International Consultative Workshop • December 17-18, 2012 • • Day 1 • 4:30 -- 6:30 P.M. Panel IV: Discussion of HPAI H5N1 Gain-of-Function Research Case Studies • • Presentations of Case Studies: • The panelists will be presented with and discuss case studies that illustrate how the HHS Framework, presented in Panel III, would apply to different HPAI H5N1 GOF research projects. • • Discussion Questions: • 1. How well did the proposed Framework function in the analysis of the case studies? Is it a useful tool for guiding funding decisions? • 2. Does the Framework appropriately address the range of risks associated with the research? • 3. Does the Framework provide for the appropriate review of such research? • 4. Are there gaps that should be addressed by the Framework? • • Panel Co-Moderators: • Dennis Dixon, Ph.D. • Chief, Bacteriology and Mycology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA • Amy P. Patterson, M.D. • Associate Director for Science Policy, National Institutes of Health, USA • • Panelists: • Tjandra Aditama, M.D. • Director-General, Disease Control and Environmental Health, Ministry of Health, Indonesia • Daniel Altmann, Ph.D. Head of Pathogens, Immunology and Population Health, Wellcome Trust, United Kingdom • Nancy Cox, Ph.D. • Director, Influenza Division, Office of Infectious Diseases, Centers for Disease Control and Prevention, USA • Thomas Inglesby, M.D. • Director, Center for Biosecurity, University of Pittsburgh Medical Center, USA • Joseph Kanabrocki, Ph.D. • Assistant Dean, Biosafety, and Associate Professor of Microbiology, University of Chicago, USA • Yoshihiro Kawaoka, D.V.M., Ph.D. • Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, USA • J. S. Malik Peiris, M.D., Ph.D. • Professor, Centre of Influenza Research and the School of Public Health, The University of Hong Kong, China • Adel Mahmoud, M.D., Ph.D. • Professor, Molecular Biology and Public Policy, Princeton University, USA • Robin Robinson, Ph.D. • Director, Biomedical Advanced Research and Development Authority, Deputy Assistant Secretary for Preparedness and Response, Department of Health and Human Services, USA

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