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Crystallization Seeding Process – Application Webinar – METTLER TOLEDO – en
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=kCTh9x1Vi5Q
A great way to introduce a degree of repeatability and consistency in batch crystallization processes is via the use of a crystallization seeding system. https://www.mt.com/us/en/home/library... • Crystallization seeding is critical in process behavior, efficiency, and product quality. Inconsistent filtration rates, drying times, yields, bulk density, flow properties, and particle size distributions can often be traced back to inconsistent seeding and nucleation. Many parameters must be taken into consideration when designing a seeding strategy such as seed size, seed loading (mass) and seed addition temperature. • These parameters are generally optimized based on process kinetics and the desired final particle properties and must remain consistent during scale-up and technology transfer. Monitoring the seed behavior in situ, during the crystallization, provides an advantage during the design and scale-up of the seeding strategy. • The 15-30 minutes following seed addition are the most critical period in ensuring the effectiveness of the seed. Mapping the seed behavior inline is often critical to ensure the batch proceeds as expected, and understanding seeding parameters means less experiments are necessary to optimize a crystallization. Advanced crystallization seeding techniques have been investigated as possible alternatives to the traditional approach. One method is to create the seed bed in-process through nucleation and growth while controlling the particle size using inline particle characterization - such as with ParticleTrack with FBRM technology. • The seed bed is created in process with direct feedback control of the seed bed is enabled by monitoring particle dimension and count in real time, allowing a final product of a specific particle size distribution with desired downstream and powder properties to be targeted. • This approach can offer significant advantages for processes where safety is a primary concern.
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