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β1Integrin The sneaky coconspirator to reovirus entry into host cells
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=l2SHajAlsEM
Read the paper: https://www.doi.org/10.1038/s41467-02... • Transcript: • Like similar viruses, reovirus is highly skillfull at getting past our cells’ defences. Its goal is to break through the plasma membrane of host cells and initiate replication once inside. • But it does not gain entry alone: it relies on a sneaky team of several co-conspirators, some of them unknown and hidden in the dark. • A new suspect is the β1-integrin, but we need more evidence to clarify its role as an accomplice to reovirus entry. • Does β1-integrin interact directly with reovirus? and how does it mediate reovirus entry into the host cell? • Therefore, researchers from Université catholique de Louvain used cutting edge atomic-force microscopy in combination with advanced imaging approaches to investigate reovirus binding to β1-integrin. • In essence, they put the virus at the end of fishing rod and threw it onto the cell to measure where it binds and with what force: identifying the lock, the receptor, and the key on the virus. • While the most recognised entry point for viruses is via junctional adhesion molecule-A, the researchers discovered new evidence directly implicating β1-integrin. They demonstrated that a direct interaction of reovirus with β1-integrin mediates clathrin recruitment on host cells: not only discovering a new entry key, but also a new lock. • This new understanding of the complex interplay between reovirus and β1-integrin is a big step. It could assist in the development of some key medical breakthroughs: • the development of broad-spectrum antiviral therapies targeting similar viruses like coronavirus, adenovirus, picornavirus and • more targeted virus-based anti-cancer treatments.
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