Targeting Proteomics to Decipher Biology for the Drug Development Pipeline

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=lv_wbYhMSfw

▶︎Visit the Proteomics Analytics Resource Center: https://cst-science.com/e3znri • In this webinar, Jeffrey Silva, PhD, Principal Scientist in the Proteomics Group at Cell Signaling Technology, will provide an overview of how mass spectrometry-based proteomics can be used for drug discovery and development. Dr. Silva will also present several case studies highlighting how these techniques can be used to gain a deeper understanding of disease mechanisms and as a powerful tool for drug discovery. • 0:00 Introduction • 1:20 The Proteome is Highly Complex • 2:40 About CST Proteomics Services • 5:56 CST Proteomics: Sample Requirements • 6:32 Global Protein Profiling • 9:01 Post-Translational Modification Profiling • 12:16 Organelle-Directed (i.e. Membrane Proteins) • 13:29 ALK: Bench to Bedside • 15:39 PTMScan Case Studies: Decrypting Drug Interactions • 19:05 Dosing Fold-Change Volcano Plots • 23:28 Time-Resolved Proteomics • 26:11 Interrogating cAMP-Dependent Kinase Signaling • 31:43 High-Throughput Ubiquitin Enrichment • 34:38 CST Proteomics Services Products Overview • 36:27 What's the advantage of an antibody enrichment approach for biomarker discovery? • 38:34 Recommendations to characterize series of drug candidates for targeted protein degradation? • 41:16 Can CST services use FFPE clinical samples? • 43:30 Is more sample needed to study multiple PTMs? • 45:44 Can PTMScan increase the impact factor of a publication? • 49:01 Strategy to compare secretome from varying cell number? • 51:10 Any disadvantages of sequential enrichment? • 54:08 Advantages of PTMScan vs global or IMAC methods? • About us: Cell Signaling Technology (CST) is a different kind of life sciences company—one founded, owned, and run by active research scientists, with the highest standards of product and service quality, technological innovation, and scientific rigor. We are a company of caring people driven by a devotion to facilitating good science—a company committed to doing the right thing for our Customers, our communities, and our planet. https://cellsignal.com/about • All trademarks are the property of their respective owners. For the latest trademark information, visit https://cellsignal.com/trademarks

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