Effects of Schistosomiasis on the Liver Hepatic schistosomiasis Causes symptoms diagnosis pre

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The effects of Schistosomiasis on the liver include: • *Liver enlargement*: Common in advanced cases, and is frequently associated with an accumulation of fluid in the peritoneal cavity and hypertension of the abdominal blood vessels. • *Hepatic fibrosis*: The extensive deposition of extracellular matrix (ECM) in the periportal areas is a typical symptom of hepatic fibrosis, giving rise to blockage of the portal veins, portal hypertension, splenomegaly, and gastrointestinal varices. • *Egg-induced granuloma formation*: The enormous amounts of eggs deposited in the host’s liver trigger the primary pathology of schistosomiasis, which includes egg-induced granuloma formation, subsequent chronic inflammation, and eventual fibrosis due to the host immune response. • *Portal hypertension and ascites*: Without prompt treatment, liver fibrosis can further transform into portal hypertension and ascites, which are usually the main causes of death in patients with chronic schistosomiasis. • #Schistosomiasis

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