Switching towards IgA

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The switching towards IgA is mainly regulate by Th2 lymphocyte activation with production of TGF-β, IL-4, IL-5, IL-13 cytokines. The secreted IgA dimer binds to a receptor (pIgR) on the basal surface of the epithelial cells. The complex is internalized into the cell and, before to migrate across the luminal surface, the receptor is cleaved and the IgA remain to bound to the receptor residue (secretory component). • https://www.pig333.com/immunology/the...

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