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Invasion and Metastasis Hallmarks of CancerRobbins pathology chapter 6Neoplasiarobbinspathology
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Invasion and Metastasis |Hallmarks of Cancer|Robbins pathology chapter 6|Neoplasia#robbins#pathology • Sustained Angiogenesis of Cancer |Hallmarks of Cancer, #neoplasia #pathology #robbins #cancer • #pathology #neoplasia #mbbsstudent • Altered Cellular Metabolism |Hallmark of Cancer|Warburg Effect #neoplasia #robbins #pathology #patho • 2nd Hallmarks of Cancer,part 1|Insensitivity to Growth Signals|Carcinogenesis #pathology#neoplasia • carcinogenesis there are 2 steps: Initiation and Promotion. • Hallmarks of cancer • 8 fundamental changes Protooncogenes, oncogenes Oncoproteins Role of Oncogenes in cancer • Triggered by a series of acquired mutations • Affecting a single cell and its clonal progeny HALLMARKS OF CANCER • 1. Self sufficiency in the growth Signals • 2. Insensitivity to antigrowth/ growth inhibitory signals • 3.Evasion of Apoptosis • 4. Limitless Replicative Potential 5. Sustained Angiogenesis, • 6. The Ability to invade and Metastasize 7.Reprogramming Energy Metabolism, • 8. Evasion of Immune Systemenablers • 9. Genomic Instability 10. Tumor promoting inflammation, • SELF SUFFICIENCY IN GROWTH SIGNALS, • Oncogenes: They promote unregulated proliferation/Autonomous cell growth • (Self sufficiency in growth signals) • The unmutated counterparts of Oncogenes are proto oncogenes • Growth factors: Cancer cells develop growth self sufficiency (Synthesize self responsive growth factors) Eg: a. PDGF Glioblastomas • b. TGF-a Sarcomas • c. FGF Breast ca 2. Growth factor receptors:Cancer cells encode for growth • factro receptors. a. EGF-receptor family: ERB-B1 (overexpression) • Squamous cell carcinoma • b. CSF-1 receptor: FMS (point mutation) - Leukemia c. PGDF receptor: PGDF-R (overexpression) - Gliomas 3. Signal transduction proteins - Receive growth • promoting signals. • Eg. RAS family (point mutation) - Ca colon, lung • Pancreas • 4. Nuclear regulatory proteins: Transcriptional activators Eg: C-MYC (translocated) - Burkitt lymphoma N-MYC (Amplification) - Ca lung, • 5. Cell cycle regulatory proteins: Eg: Cyclin D (Translocation) Ca breast, Ca esophagus CDK4 (Amplification) Melanoma • Genetic Lesions in Cancer,part 1,Diver and Passenger Mutations,Robbins Pathology chapter 6,Neoplasia • Cancer genes,proto oncogenes, Tumour suppressor gene, Apoptotic and Anti Apoptotic genes #pathology • Characteristics of Benign and Malignant Neoplasms,Part-2,Local invasion, Metastasis#pathology#neoplasia • Local invasion; • This spread is a cellular process, in which cancer cells become mobilized and invade out and away from the primary tumor site. Local invasion causes debilitating tissue and organ destruction in glioma and lung • Metastasis; • In metastasis, cancer cells break away from the original (primary) tumor, travel through the blood or lymph system, and form a new tumor in other organs or tissues of the body. The new, metastatic tumor is the same type of cancer as the primary tumor. • Characteristics of Benign and Malignant tumors||Differentiation and anaplasia||Dymoplasia #neoplasia • Like video,Share and subscribe so that more people can get benefits, • • anaplasia,differentiation,differentiation and anaplasia /of neoplasia(1),diffreniciation and anaplasia,differentiation vs anaplasia,anaplasia definition,anaplasia meaning,#anaplasia,what is anaplasia,cellular adaptation of growth and differentiation,anaplastic,differenciation,what does anaplasia stand for,metaplasia and dysplasia,anaplasia explanation,lack of differentiation,anaplasia pronunciation,anaplasia dictionary,cell differentiation • benign tumor,characteristics of benign and malignant tumors anaplasia,malignant tumor,malignant,properties of benign and malignant tumor,benign and malignant tumors,malignant tumours,characteristics of benign malignant neoplasms,benign,charecters of benign tumor malignant tumor,benign and malignant tumors pathology,benign tumor and malignant tumor,benign tumours,difference between benign and malignant tumor,differences between benign and malignant tumor • Like video,Share and subscribe so that more people can get benefits, • Nomenclature of Neoplasia, Components of Neoplasia,Mixed Tumor,Teratoma#pathology#neoplasia#robbins • Neoplasia|Robbins Pathology chapter 6|Introduction to Neoplasia robbins_pathology#pathology#cancer • neoplasia,neoplasia definition,neoplasia maligna,malignant neoplasia, • Brainless Medico • Bell Icon For More Videos • medical study tips, • medical study in hindi, • medical study in canada, • medical study in germany, medical study in usa, • medical study point, • medical study with me, • medical study vlog, • medical study abroad, • how to study medical books, medical study center, • medical for canada study visa, medical college study, • medical coding study guide, • medical study diary • neoplasia pathology robbins, • neoplasia pathology, • neoplasia pathology in hindi, • neoplasia,neoplasia i love pathology, • neoplasia pathology lecture, • neoplasia pathology selfless medicose
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