Sentinel Node Biopsy Breast Cancer Lymph Node Surgery











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When our bodies get an infection, the immune response is coordinated inside the lymph node. A whole range of different cell types need to work together inside the lymph node to put together this response. • In this video, we discuss some of the work done by the Acton Lab at the MRC Laboratory for Molecular and Cell Biology at University College London. They investigate how the various cell types inside a lymph node (including dendritic cells, T-cells, and fibroblasts) communicate with one another to build a strong immune response. This includes cellular signalling that changes the actual shape of the lymph node. • For more information about the Acton Lab, please visit: • https://www.actonlab.co.uk • http://www.ucl.ac.uk/lmcb/users/sophi... • References: • Acton, S. E., Reis e Sousa, C. (2016). Dendritic cells in remodeling of lymph nodes during immune responses. IMMUNOLOGICAL REVIEWS • Fletcher, A. L., Acton, S. E., Knoblich, K. (2015). Lymph node fibroblastic reticular cells in health and disease. NATURE REVIEWS IMMUNOLOGY • Acton, S. E. et al. (2014). Dendritic cells control fibroblastic reticular network tension and lymph node expansion. NATURE • Acton, S. E. et al. (2012). Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. IMMUNITY

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