NETOSIS neutrophil extracellular traps role in pathology and possible therapeutic targets

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#netosis #neutrophilextracellulartraps #immunothrombosis NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules cytoplasm. NETosis plays an Important role in thromboinflammation. Immunothrombosis is the the complex network between the coagulation system the innate immune system. Thrombosis actually is a protective reaction against pathogens, facilitating their capture in a fibrin clot. Excessive NETosis has been suggested to play an important role in pathogenesis of many infectious (covid 19), inflammatory (atheroscleosis), autoimmune diseases (SLE). The development of new drugs preventing NETosis, including mitochondria-targeted antioxidants, appears to be a promising area of pharmacological research. • 🔔subscribe for more free Derma Immunology videos: https://www.youtube.com/@dermaimmunol... • References: • https://www.ncbi.nlm.nih.gov/pmc/arti.... • https://www.ncbi.nlm.nih.gov/pmc/arti... • https://www.ncbi.nlm.nih.gov/pmc/arti... • https://www.ncbi.nlm.nih.gov/pmc/arti... • Key moments: • 00:00 Introduction • 02:35 Role in thrombosis • 04:01 Role in atherosclerosis • 05:12 Role in crystal formation • 05:59 Role in lung diseases • 09:56 Role in autoimmune diseases • 12:43 Role in skin diseases • 15:56 Possible therapeutic targets • PLAYLISTS: • • Exploring the Role of IL17 IL17 Pro... • • Thymic Stromal Lymphopoietin video #... • • Innate Lymphoid cells (innate counter... • • Thromboinflammation: Neither thrombos... • • The Hidden World of NETosis: Unraveli... • • The Role of Inflammation in Depressio... • • Video • • EXTRA CELLULAR VESICLES (Exosomes, Mi... • • Ferroptosis; redox and iron oxidative... • • DAMPs damage or danger associated mol... • • Autoinflamation psoriasis pathogenesis • • Epigenetics; controlling genes expr... • • How can I get enough Vitamin D??? • • Natural Killer T cells basics introdu... • • How can I get enough Vitamin D??? • For more information: • Web site: https://dermatologytrend.com • Facebook page: / dermatoltrend • LinkedIn: / naglaa-nabil-elmongy-5445a033

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