Jnk Pathway











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Jnk Pathway - This lecture explains about the jnk signaling pathway or c jun n terminal kinase pathway that leads to the apoptosis or cell death. Stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) are members of the MAPK loved ones and are activated by a form of environmental stresses, inflam- matory cytokines, progress reasons, and GPCR agonists. Stress indicators are delivered to this cascade by way of small GTPases of the Rho household (Rac, Rho, cdc42). As with the other MAPKs, the membrane proximal kinase is a MAPKKK, most commonly MEKK1â��four, or a member of the combined lineage kinases (MLK) that phosphorylates and prompts MKK4 (SEK) or MKK7, the SAPK/JNK kinases. On the other hand, MKK4/7 can also be activated through a member of the germinal core kinase (GCK) family in a GTPase-unbiased method. SAPK/JNK translocates to the nucleus the place it might probably keep an eye on the pastime of multiple transcription causes. • For more information, log on to- • http://www.shomusbiology.com/ • Get Shomu's Biology DVD set here- • http://www.shomusbiology.com/dvd-store/ • Download the study materials here- • http://shomusbiology.com/bio-material... • Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- • Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store • Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help • Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching • We are social. Find us on different sites here- • Our Website – www.shomusbiology.com • Facebook page-   / shomusbiology   • Twitter -   / shomusbiology   • SlideShare- www.slideshare.net/shomusbiology • Google plus- https://plus.google.com/1136485849827... • LinkedIn -   / suman-bhattacharjee-2a051661   • Youtube-    / thefunsuman   • Thank you for watching

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