Polymyxin Mechanism Of Action Antimicrobial Spectrum Adverse Effects

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=q5ztVWWMVMc

#pharmacology #medicine #drugs #antibiotics #polymyxin • Polymyxins are bactericidal drugs and act on the outer membrane of gram-negative bacteria by destabilizing the phospholipids and lipopolysaccharides (LPS) present. There is an electrostatic interaction between the positively charged polymyxin and the phosphate groups of the negatively charged lipid A membrane, which causes displacement of divalent cations such as calcium and magnesium from the phosphate groups within these membrane lipids. This activity leads to increased permeability, a disrupted outer cell membrane, and intracellular contents begin to leak out, resulting in cellular bacterial death. Also, polymyxins can neutralize the endotoxin effect of pathogens. The endotoxin portion of gram-negative bacteria corresponds to the lipid A part of the LPS. Polymyxins can bind to the LPS released as a result of cellular death, which results in the neutralization of the endotoxin and thus reduces its effects in the circulation.

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