Streptococcal Infections and Glomerulonephritis











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Poststreptococcal glomerulonephritis (PSGN) is a type of kidney disease that can occur following certain infections caused by Streptococcus bacteria, particularly Group A Streptococcus (Streptococcus pyogenes). It is characterized by inflammation of the glomeruli, which are the tiny filtering units in the kidneys responsible for removing waste products and excess fluids from the blood. • PSGN most commonly occurs in children and young adults, typically a few weeks after an initial infection, such as strep throat or skin infections like impetigo. It is an immune-mediated response, where the body's immune system reacts to the streptococcal infection by producing antibodies. Sometimes, these antibodies can deposit in the glomeruli, triggering an inflammatory response that damages the kidney tissue and disrupts its normal function. • Key characteristics of Poststreptococcal Glomerulonephritis include: • 1. *Hematuria (blood in urine):* One of the most common symptoms is the presence of blood in the urine, which can give the urine a reddish or brownish color. • 2. *Proteinuria (protein in urine):* Another common symptom is the presence of protein in the urine, which can cause foamy urine. • 3. *Edema (swelling):* Swelling, particularly around the eyes, hands, feet, and ankles, is also a common symptom. This occurs due to the kidneys' reduced ability to remove excess fluids and waste products from the body. • 4. *Hypertension (high blood pressure):* The inflammation and damage to the glomeruli can disrupt the kidneys' ability to regulate blood pressure, leading to elevated blood pressure levels. • 5. *Flank pain:* Some individuals may experience mild to moderate pain or discomfort in the area of the lower back, just below the ribs. • 6. *Reduced urine output:* As the kidney function becomes impaired, urine output may decrease. • Diagnosis of PSGN typically involves a combination of medical history, physical examination, laboratory tests, and sometimes a kidney biopsy. The presence of a recent streptococcal infection, along with characteristic symptoms and laboratory findings (such as elevated levels of creatinine, reduced kidney function, and the presence of blood and protein in the urine), can help confirm the diagnosis. • Treatment for PSGN primarily involves managing the symptoms and supporting the kidneys' function while the body naturally resolves the immune response. This may involve bed rest, a low-salt diet to manage edema, and medications to control blood pressure and reduce swelling. In most cases, the condition improves within a few weeks to months as the immune response subsides and the kidneys heal. In severe cases, where kidney function is severely compromised, more intensive medical treatment may be required. • It's important to note that while PSGN is most commonly associated with streptococcal infections, other infections and conditions can also cause similar glomerular inflammation. 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