This Is Why Methylfolate Makes You Feel Worse

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Are you taking methylfolate and can't figure ouhave you been taking methylfolate and can't figure out why the methylfolate makes you feel worse maybe you've tried different dosing strategies taking smaller amounts skipping days et cetera. Iin this video look at three main reasons methylfolate can make people feel worse when they take it • Glycine I use: https://geni.us/Ax6pIs (Amazon affiliate link) • Chris Masterjohn Glycine video: • Does Methylfolate Make You Angry or D... • **MY COURSE ⭐️ : Get real-world troubleshooting and personal guidance to optimize your health through genetics with this comprehensive MTHFR course. • http://discover-holistic-health-acade... • **MY BOOK 📕 : Skip the common pitfalls and fast-track your journey to optimal health. https://geni.us/y6lNt (Amazon Affiliate Link) • We look at why methylfolate makes you feel worse and related topics on mthfr gene mutation like methylfolate side effects. There are a number of reasons why this can happen but i would but most of the reasons fall into three main categories number one digestive number two inability to buffer the neurostimulating • 00:00 Introduction to Methylfolate Side Effects • 00:17 Digestive Issues Linked to Methylfolate • 01:09 Neurological and Stress-Related Effects of Methylfolate • 02:58 Understanding Methylfolate Trapping • and overall stimulating effect of the methylfolate and then number three is methylfolate trapping. the digestive issues are fairly straightforward when you have ongoing digestive issues problems like gas bloating pain diarrhea oftentimes not always but oftentimes • this is related to bacterial or fungal overgrowth. many times this is in the small intestine. The methyl folate can act as a growth factor or enhancer. Basically it helps those microbes grow b vitamins are known as growth factors for bacteria and yeast so that when you take them those microbes are able to grow and expand . That leads to increased local in the digestive tract symptoms and also systemic symptoms could be headaches body aches numbness tingling, lots of immune related symptoms and lots of • neurological related symptoms. If you think you have this problem going on then you need to treat the underlying digestive issue or take other things that can support the overall methylation pathways without stimulating this growth the other thing that i want to talk about is the inability to buffer the stimulating effect of methylfolate one of the properties of methylfolate is to help your body make neurotransmitters. If you're deficient in the methylfolate due to genetics or some other reason and you're deficient in folate, taking it will have a stimulating effect. Sometimes and for some people, it's uncomfortable because it's too stimulating and part of that is because they don't have the ability to buffer that stimulating effect so if you're already somebody that tends to be • stressed anxious can't sleep well taking methylfolate may make that worse. one of the reasons for this probably is because of glycine. Folates in general help your body hold on to glycine and recycle glycine. Deficiency in folate or methylfolate can lead to glycine deficiency this was also described by chris masterjohn phd. Glycine acts like a calming neurotransmitter by activating the gaba part of our brain gaba is the main calming neurotransmitter and kind of acts like a break for all the stimulating effect of the other neurotransmitters like the catecholamines so gaba is an independent calming neurotransmitter and glycine can help your body increase the amount of gaba activation in the body so these are really the only two main calming neurotransmitters that we have and glycine is technically an amino acid but if you don't have enough of it you can't buffer or break some of that stimulating effect that's happening from the methyl folate you also see this commonly with high cortisol levels glycine helps reduce cortisol levels through the same mechanism of activating the gabanergic system glycine is very safe very effective at calming down your nervous system and if you do have genetic alterations in folate metabolism you may benefit from some glycine supplementation especially if you're having trouble with sleep and generally anxious check out the description if you want to see the one that i often use for my patients now the last thing is methyl folate trapping so methyl folate trapping can be a little bit complicated if you're not familiar with the overall methylation or methionine synthase pathway you may want to look up a diagram of that and also folate metabolism but the basics of it are if you don't have enough b12 or enough homocysteine the methionine synthase enzyme is not really working and because of that that methyl folate gets trapped there because you need all three of those things for that enzyme to actually push forward and make homocysteine turns into methionine

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