What is multimodal analgesia London Pain Clinic











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The body has its own pain relief system that gets activated when experiencing pain. • . • As a painful stimulus ascends to the cerebral cortex (to become consciously aware of the pain) it sends signals to multiple other areas of the brain. This includes: • Amygdala (emotion) • Hypothalamus (flight/fight response) • Reticular formation (arousal and consciousness) • . • 1️⃣All of these regions, including the cortex, will send a signal to the • 2️⃣Magnus Raphe Nucleus (located at the midline of the medulla) and will • 3️⃣Send a serotonergic signal to the spinal cord • 4️⃣Stimulate a neuron in the spinal cord that releases Enkaphalin (opioid) • 5️⃣Enkephalin will bind to opioid receptors (delta opioid receptors) of both the pre- and post- synaptic pain neuron. • 6️⃣Stopping the pain signal!! • Listen to our podcast for more info: https://podcasts.apple.com/au/podcast...

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