ATROPINE Mechanism Uses Adverse effects Antidote Pharmacokinetic PHARMACOLOGY

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=tghr00NU-CU

Atropine is an antimuscarinic agent which is actually a tertiary amine and a belladonna alkaloid. Atropine compete with acetylcholine to bind with muscarinic receptor. Atropine cause mydrasis, cycloplegia and cause increase of intraocular pressure. Atropine act as antispasmodic agent. At low, atropine cause the decrease of heart rate and at high doses atropine cause increase of heart rate, so can be use in bradycardia. It causes the inhibition of body secretions, causing xerostomia, increase in body temperature. Organophosphate poisoning is treated with atropine. Physostigmine toxicity can be reversed by atropine. Mushroom poisoning can also be reversed by atropine. Atropine can cross CNS thats why can overcome CNS toxic effects. Adverse effects include dry mouth, tachycardia, urinary retention, constipation, Restlessness, confusion, delirium, depression and collapse of Circulatory and respiratory system thus cause death. Physostigmine is antidote for atropine toxicity. Pharmacokinetics includes Atropine can be absorbed orally and metabolized by liver partly and eliminated by urine. Systemic intake of atropine has half life of 4 hours whereas ophthalmically applied atropine has much greater half life which is up to days. • • #atropine #organophosphate #antimuscarinicagent

#############################

New on site