Youtor
AMYLOIDOSIS PART 2 Pathogenesis amp Classification
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=v9x6W7sza3w
The Part 2 of 3 parts tutorial on Amyloidosis.In this part i have described the Pathogenesis and Classification of Amyloidosis.Visit http://ilovepathology.com/ for more topics in Pathology! • ***Follow me**** • to view AMyloidosis Part 1 Click here: • AMYLOIDOSIS: Part 1: Definition, Hist... • Twitter : / vijaypatho • / ilovepathology2 • Facebook: / ilovepathology • AMYLOIDOSIS 2 • PATHOGENESIS: Basic Mechanism • Abnormal folding of proteins/ Misfolded proteins • Mechanism of damage to the tissues • Pressure effect: leading to atrophy • Accumulation in vessel wall : Leading to ischemia and also increased permeability • Direct cytotoxicity: eg, Amyloidogenic light chain accumulation n cardiac cells • Prefibrillar oligomers: are found be more injurious than actual fibrils. In Alzheimer's and ATTR Amyloidosis • Localised amyloidosis • Limited to a single tissue or organ • Can be only microscopic foci or may be evident grossly as nodular masses • The common sites: lung, larynx, skin, bladder, tongue etc. • Microscopic findings: Lymphocytes and plasma cells can be seen in the periphery of amyloid deposits. • Some cases , the amyloid consists of AL protein
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