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Cahn Ingold Prelog Priority Rules Rules to ASSIGN S and R Configuration
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http://youtube.com/watch?v=vLiAyRQg72A
This video talks about Cahn Ingold Prelog Priority Rules. The Cahn-Ingold-Prelog priority rules are a set of guidelines used in stereochemistry to assign priorities to substituents around a chiral center. These rules help determine the absolute configuration of a chiral molecule, specifically whether it is in an S (sinister, Latin for left) or R (rectus, Latin for right) configuration. • Cahn-Ingold-Prelog Priority Rules: • 1. Atomic Number Priority: • Assign priorities to substituents based on the atomic numbers of the atoms directly bonded to the chiral center. The higher the atomic number, the higher the priority. Hydrogen is usually assigned the lowest priority. • 2. Multiple Bond Consideration: • If there is a tie in atomic numbers, consider the atoms farther along the chain. Treat multiple bonds as equivalent to the same number of single bonds for the purpose of priority assignment. • 3. Compare Substituent Atoms: • If the atoms directly bonded to the chiral center are the same, compare the atoms farther along the chain until a point of difference is found. • 4. Ranking Isotopes: • When dealing with isotopes, prioritize based on the higher atomic mass. • Steps to Assign S and R Configurations: • 1. Identify the Chiral Center: • Locate the carbon atom with four different substituents. • 2. Assign Priorities: • Use the rules to assign priorities (1, 2, 3, 4) to the substituents based on atomic numbers. • 3. Orient the Lowest Priority Away: • Mentally rotate the molecule if needed so that the lowest priority substituent is pointing away from you. • 4. Visualize the Sequence: • Visualize the sequence of priorities when looking from the highest to the lowest priority. • 5. Determine Configuration: • If the sequence is clockwise, it is assigned the R configuration; if counterclockwise, it is assigned the S configuration. • This video will help you learn the basics and foundational knowledge needed to ace your exams! • Timestamps • 0:00 Intro • 0:27 Cahn-Ingold-Prelog Priority Rules • 0:37 Rule 1 - Assigning1priority based on atomic numbers • 1:36 Tied priority groups • 1:48 If multiple types of bonds exist • 2:03 Rule 2 - Spatially re-arranging the molecule • 2:31 Rule 3 - Determine if S or R configuration • 3:20 Applying the Cahn-Ingold-Prelog Priority Rules with an example • 5:36 Enantiomers and S and R configuration • 6:02 Outro • Thanks for watching! • I hope this was helpful for you. • ------------------------------------------------------------------------------------------------------------ • **Subscribe for more free lessons: / @themedtutor** • ------------------------------------------------------------------------------------------------------------ • Check Out Some of Our Other Lessons • Biochemistry Playlist: • • Biochemistry • Chemistry Playlist • • Chemistry • Anatomy Playlist • • Anatomy • Cell Biology Playlist • • Cell Biology • Amino Acids Playlist • • Amino Acids | MCAT Biochemistry
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