Boronic esterlinked macrocycles as warheads against serine proteases

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By attaching a diol to the P2 side chain, stable boronic esters form spontaneously. These protected esters can by used as building blocks in antibiotics to inhibit the serine protease LepB of E. coli. For more information, read our recent article in European Journal of Medicinal Chemistry 157 (2018) 1346e1360: • https://authors.elsevier.com/a/1Xgrw_...

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