common bases for deprotonating ketones to make enolates











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directory of Chem Help ASAP videos: https://www.chemhelpasap.com/youtube/ • Organic chemists have many strong bases to choose from for deprotonating a ketone to make an enolate. Among all the bases, the most common, by far, is lithium diisopropylamide, or LDA. LDA is strong enough to form a high concentration of the enolate and bulky enough so that it will not attack the carbonyl as a nucleophile. Under special circumstances, sodium hydroxide and related alkoxides can be used to generate low concentrations of enolates.

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