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De Novo synthesis of Purines made easy Purine synthesis easy method Biochemistry
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Video Source: www.youtube.com/watch?v=MGmOSYiguag
This video is about : • Mnemonic for De Novo synthesis of Purines : Easy way to remember Purine synthesis in Biochemistry • Purine synthesis • How to remember purine synthesis in biochemistry • Easy way to remember de novo purine synthesis • Simple way to remember de novo purine synthesis in Biochemistry • The de novo synthesis of purines is a complex metabolic pathway through which cells produce purine nucleotides, the building blocks of DNA and RNA. This pathway involves several enzymatic reactions and requires multiple precursor molecules, including amino acids, carbon dioxide (CO2), and energy-rich compounds like adenosine triphosphate (ATP). Here is an overview of the major steps involved in the de novo synthesis of purines: • 1. Ribose-5-phosphate Production: The pathway begins with the conversion of glucose-6-phosphate, derived from glucose metabolism, into ribose-5-phosphate. This conversion occurs via a series of enzymatic reactions known as the pentose phosphate pathway. • 2. Formation of PRPP: Ribose-5-phosphate is converted into 5-phosphoribosyl-1-pyrophosphate (PRPP) by the enzyme PRPP synthetase. PRPP serves as a key precursor molecule for the subsequent steps in purine synthesis. • 3. Formation of Inosine Monophosphate (IMP): IMP is the first purine nucleotide formed in the de novo synthesis pathway. The conversion of PRPP to IMP involves a series of enzymatic reactions, including the incorporation of atoms from glutamine, glycine, aspartate, and formyl-tetrahydrofolate. • 4. Synthesis of Adenosine and Guanosine Nucleotides: IMP acts as a branch point in the pathway, leading to the formation of either adenosine monophosphate (AMP) or guanosine monophosphate (GMP). Additional enzymatic reactions, including the conversion of IMP to adenylosuccinate and xanthosine monophosphate (XMP) to guanosine monophosphate (GMP), are involved in the production of these nucleotides. • 5. Conversion to Higher Nucleotides: AMP and GMP can be further phosphorylated to produce adenosine diphosphate (ADP), adenosine triphosphate (ATP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These high-energy nucleotides serve as essential cellular energy sources and play crucial roles in various biochemical processes. • The de novo synthesis of purines is tightly regulated to ensure the balanced production of nucleotides based on cellular needs. The regulation involves feedback mechanisms and control points at key enzymatic steps within the pathway. • While de novo synthesis is one route for purine production, cells can also obtain purines from the diet or salvage pathways that recycle purine bases from degraded nucleotides. Together, these processes maintain an adequate supply of purine nucleotides for DNA and RNA synthesis and other cellular functions. • Join through this link @ / @biochemistryconcepts • #biochemistry • #biology • #neet • #biochem • #mnemonics • #purines • #neucleotides • #dna • #rna • #metabolism • #pathways • #synthesis #easy #easybiology • #purinesynthesis • #mbbs • #mbbsmotivation • #bds • #bdsexams • #mbbsexams • #medicalmnemonics • #mnemonics mbbs • #physiotherapy • #bscbiotechnology • #biologytricks • #biochemistry • #nursing • #purinesynthesisbiochemistry • #purinesynthesis
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