JC91 PhosphorothioateDNA bacterial diet reduces theROS levels inVerna

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🔎📰 Paper: • Phosphorothioate-DNA bacterial diet reduces the ROS levels in C. elegans while improving locomotion and longevity. • Qiang Huang, Ruohan Li, Tao Yi, Fengsong Cong, Dayong Wang, Zixin Deng Yi-Lei Zhao. • Commun Biol. 2021 Nov. • doi: 10.1038/s42003-021-02863-y • https://www.nature.com/articles/s4200... • Abstract: • DNA phosphorothioation (PT) is widely distributed in the human gut microbiome. In this work, PT-diet effect on nematodes was studied with PT-bioengineering bacteria. We found that the ROS level decreased by about 20–50% and the age-related lipofuscin accumulation was reduced by 15–25%. Moreover, the PT-feeding worms were more active at all life periods, and more resistant to acute stressors. Intriguingly, their lifespans were prolonged by ~21.7%. Comparative RNA-seq analysis indicated that many gene expressions were dramatically regulated by PT-diet, such as cysteine-rich protein (scl-11/12/13), sulfur-related enzyme (cpr-2), longevity gene (jnk-1) and stress response (sod-3/5, gps-5/6, gst-18/20, hsp-12.6). Both the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis suggested that neuroactivity pathways were upregulated, while phosphoryl transfer and DNA-repair pathways were down-regulated in good-appetite young worms. The findings pave the way for pro-longevity of multicellular organisms by PT-bacterial interference. • Critical assessment of this research publication is for scientific/education purposes only. • 🌐COIL Program: • This video belongs to the Collaborative Online International Learning (COIL) Program of SJTU, which aims to create international collaborations between labs to enhance students' presentation skills and foster critical thinking. For the semester running from September 2023 to January 2024, ivLab @ Shanghai Jiao Tong University is collaborating with Dr. Awan's Human Molecular Genetics and Metabolic Disorders Group from the Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Pakistan. • ivLab @ Shanghai Jiao Tong University • http://vinnikov.science • https://x.com/vinnikovLAB

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