New drug reveals a key mechanism to overcome resistance to protein degraders

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Scientists at ‪@IRBBarcelona‬ identify a promising drug, RBS-10, capable of selectively killing cells that are resistant to protein degraders, thus providing hope in overcoming such resistance. • Uncovering the pivotal role of the enzyme NQO1, this study sheds light on a key vulnerability in resistant cells and offers potential insights that could be useful for future cancer treatments. • Read more about this work, published on Angewandte Chemie, here ➡️ shorturl.at/tzDOS • #chembio #ChemicalBiology #DrugSDiscovery #ProteinDegraders #TargetedProteinDegradation #TPD #research

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