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Shibasaki Cyclization Mechanism Organic Chemistry
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Video Source: www.youtube.com/watch?v=X8afBggwQ-k
The mechanism for a Shibasaki Cyclization in which a cyclized amide is produced from a ketone starting material. A bromine is necessary in the starting material as well in order to have insertion by the palladium catalyst followed by coordination and subsequent insertion by the CO. A titanium catalyst is then introduced in order to supply the nitrogen necessary for the final amide formation. • Music by Ryan Little • Song: Portra • Link: • Ryan Little - Portra
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