Structural Activity Relationship SAR of Barbiturates

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Activity and duration of action of barbiturates is highly related to the groups at 5th position in barbiturates. Interestingly the total number of carbons, nature of chain, branching and presence of unsaturation all these factors at 5th position greatly influence lipophilicity of the drug thereby affect the duration. • #barbiturates • #phenobarbital • #barbiturateacid

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