Hydroxocobalamin and Methylene Blue in Septic Shock

############################# Video Source: www.youtube.com/watch?v=hplsUV_OR8c

In this informative lecture from ResusX: Reset (see link below for more lectures), Dr. Eddy Gutierrez discusses the potential use of Hydroxocobalamin and Methylene Blue in treating Septic Shock. Emphasizing the need for unconventional strategies due to persistently high mortality rates with current practices, Dr. Gutierrez delves into the pharmacology of these medications, particularly their impact on vasodilation and the overactive immune response seen in sepsis. • Highlighting the historical use of Methylene Blue and its Nobel Prize-winning origins, he explores its potential benefits, cautioning against potential side effects such as serotonin syndrome and oximetry errors. Additionally, he shares insights from recent trials, including the SHOCKEM - Blue trial, indicating faster discontinuation of vasopressors with Methylene Blue. • Transitioning to Hydroxocobalamin, Dr. Gutierrez discusses a pilot study showing a reduction in vasopressor requirements but acknowledges the need for further research. Addressing cost considerations, he concludes by expressing optimism about ongoing clinical trials exploring catecholamine-sparing agents for improved management of patients in Septic Shock. • 00:00 Introduction to Methylene Blue and Hydroxocobalamin • 00:38 The Problem of Sepsis and the Need for New Strategies • 02:17 Understanding the Role of Methylene Blue • 03:02 Potential Side Effects of Methylene Blue • 04:34 Previous Studies on Methylene Blue in Septic Shock • 05:47 The SHOCKEM - Blue Trial • 07:21 Introduction to Hydroxocobalamin • 07:38 Potential Side Effects of Hydroxocobalamin • 08:17 The IV Hydroxocobalamin in Septic Shock Study • 09:21 Cost Considerations and Future Directions • 10:11 Conclusion • To watch more videos from the ResusX: Reset conference, check out https://www.resusx.com/resusx-reset-r... • Hashtags: • #CriticalCare, #EmergencyMedicine, #SepticShock, #MethyleneBlue, #Hydroxocobalamin, #MedicalResearch, #InnovativeTreatment, #SepsisAwareness, #PatientCare, #HealthcareStrategies, #MedicalStudies, #ClinicalTrials, #CatecholamineSparing, #MedicalInnovation, #MethyleneBlueStudies

#############################

New on site