Molecular Mechanisms Underlying the Autophagy Processing in Cell

############################# Video Source: www.youtube.com/watch?v=lb_1DN_5brc

All Rights Are Reserved. • For educational and non-commercial use only. This video may not be edited or extracted without my permission. The use, duplication, distribution of this material for any commercial propose is strictly prohibited. • For a commercial use of this video, please contact me at • [email protected] • Thank you • another related video: • Autophagy- Molecular Mechanism of LC3 Lipidation • • Autophagy- Molecular Mechanism of LC3... • • Acknowledgment: • • Dr. Lindsay Whitton, my mentor. • Dr. Malcolm Wood, A great Expert in electron Microscopy. • All the scientists in the world of autophagy. • Manuscripts to read: • 1. Alers, S., A.S. Loffler, S. Wesselborg, and B. Stork, Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol, 2012. 32(1): p. 2-11. • 2. Axe, E.L., S.A. Walker, M. Manifava, P. Chandra, H.L. Roderick, A. Habermann, G. Griffiths, and N.T. Ktistakis, Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol, 2008. 182(4): p. 685-701. • 3. Deas, E., N.W. Wood, and H. Plun-Favreau, Mitophagy and Parkinson's disease: the PINK1-parkin link. Biochim Biophys Acta, 2011. 1813(4): p. 623-33. • 4. Itakura, E. and N. Mizushima, Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy, 2010. 6(6): p. 764-76. • 5. Klionsky, D.J., E.H. Baehrecke, J.H. Brumell, C.T. Chu, P. Codogno, A.M. Cuervo, J. Debnath, V. Deretic, Z. Elazar, E.L. Eskelinen, S. Finkbeiner, J. Fueyo-Margareto, D. Gewirtz, M. Jaattela, G. Kroemer, B. Levine, T.J. Melia, N. Mizushima, D.C. Rubinsztein, A. Simonsen, A. Thorburn, M. Thumm, and S.A. Tooze, A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy, 2011. 7(11): p. 1273-94. • 6. Levine, B., N. Mizushima, and H.W. Virgin, Autophagy in immunity and inflammation. Nature, 2011. 469(7330): p. 323-35. • 7. Mizushima, N., The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol, 2010. 22(2): p. 132-9. • 8. Mizushima, N., B. Levine, A.M. Cuervo, and D.J. Klionsky, Autophagy fights disease through cellular self-digestion. Nature, 2008. 451(7182): p. 1069-75. • 9. Polson, H.E., J. de Lartigue, D.J. Rigden, M. Reedijk, S. Urbe, M.J. Clague, and S.A. Tooze, Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy, 2010. 6(4): p. 506-22. • 10. Rubinsztein, D.C., T. Shpilka, and Z. Elazar, Mechanisms of autophagosome biogenesis. Curr Biol, 2012. 22(1): p. R29-34. • 11. Simonsen, A. and H. Stenmark, Self-eating from an ER-associated cup. J Cell Biol, 2008. 182(4): p. 621-2. • 12. Tooze, S.A. and T. Yoshimori, The origin of the autophagosomal membrane. Nat Cell Biol, 2010. 12(9): p. 831-5.

#############################

New on site