Developmental Genetics 1

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0:02:11 The central dogma • 0:03:40 Transcription factors • 0:06:10 TBP as an example transcription factor • 0:09:37 Regulatory cascades, pathway arrow nomenclature, and repression • 0:16:42 Gene expression regulation across time • 0:22:09 Cell non-autonomy and the concept of signaling • 0:23:51 Summary • 0:24:29 How development can change and why it isn't easy to: the apterous fly • 0:27:11 Hox genes and regulatory change • 0:31:56 Definition of an ortholog • 0:33:22 The fates of some mutants, like the Ubx fly • 0:35:15 Small changes are more likely to persist, e.g. gene regulation of the yellow gene • 0:42:08 Gene duplication as the substrate for evolution and development • 0:44:08 Hox clusters and the definition of a paralog • 0:48:00 Summary • 0:48:32 Hox duplications and cluster variation between species • 0:51:53 Possible fates of duplicate genes • 0:56:28 Analogies of neofunctionalization, subfunctionalization, nonfunctionalization, and redundancy • 1:01:02 Hox genes, anterior-posterior expression, and the Hox code concept • 1:03:40 Experimental approaches to studying the function of a gene in development: necessity (lose it) and sufficiency (move it)

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