Podcast 710 Droperidol vs Zyprexa

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Contributor: Nick Tsipis, MD • • Educational Pearls: • • 1. Prospective trial studied 5 mg IM droperidol to 10 mg IM olanzapine (Zyprexa) in the reducing levels of agitation • 2. Time to adequate sedation was about 16 minutes for both agents • 3. Droperidol was slightly less sedating than olanzapine and length of stay for olanzapine was longer • 4. Olanzapine had a higher rate of requiring another agent for adequate sedation • 5. Droperidol had a higher rate of adverse events (mainly extrapyramidal symptoms) than olanzapine • 6. Remember to put the safety of the staff and patient at the forefront of sedation practices and be cognizant of the psychological effect of giving involuntary medications to patients • References: • • Cole JB, Stang JL, DeVries PA, Martel ML, Miner JR, Driver BE. A Prospective Study of Intramuscular Droperidol or Olanzapine for Acute Agitation in the Emergency Department: A Natural Experiment Owing to Drug Shortages. Ann Emerg Med. 2021;78(2):274-286. doi:10.1016/j.annemergmed.2021.01.005 • • Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD • The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.org/cm... and create an account. • Donate to EMM today: https://www.paypal.com/donate/?token=... • Episode Link on Website: https://emergencymedicalminute.org/po...

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