Growing BRAIN Organoids on a CHIP Actual Research

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Organ-on-a-chip is a cutting-edge scientific technology designed to bring laboratory research closer to what happens in the body. Organoids are 3D cell culture systems designed to also better mimic processes in the human body. Why not combine these two cutting-edge biotechnologies? • That's exactly what the scientific research study referenced below did! The scientists who wrote the research paper discussed in this video put brain organoids on chips. Organ on a chip technology could lead to more accurate scientific experiments and advancements in biomedical technology. • The brain organoids were generated in the lab using human induced pluripotent stem cells (hiPSCs). Pluripotent stem cells have the unique ability to turn into nearly any cell type found in the human body, a process called differentiation. The researchers made clusters of stem cells and differentiated them into cells of the brain: brain organoids. Then, the scientists put them on microfluidic chips devices designed to more effectively mimic fluid flows and perfusion as occurs in the body. These brain-on-a-chip experiments, or rather brain organoids on a chip were a proof-of-concept that combining stem cell and organoid technology with microfluidic organ-on-a-chip technology can lead to advancements in cutting-edge scientific research devices. • But where should the ethical boundaries be? How closely should a lab-grown brain-like structure made from human cells come to approximating the real thing? The human brain of course is exceedingly complex, but as technology evolves, could this ever become a real concern? Share your opinion in the comments! • Science Is You is a growing channel dedicated to brining you reports and discussions of real, cutting-edge biotechnology research papers. To support this mission of making real scientific research available, accessible, and fun for everyone, please subscribe and spread the word! Thanks for watching! • Paper discussed in this video: • Wang, Yaqing, et al. Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system. RSC advances 8.3 (2018): 1677-1685. • #scienceisyou #biotechnology #research #brainresearch #biology #cuttingedge #technology

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