Chapter 21 Biology of Platelet Rich Fibrin presented by Dr Richard Miron

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😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/me... • With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep... • Disclaimer: I use affiliate links.... • ►👨‍🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.c... ... Check out my brand new Electrolytes course at https://www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Platelet plug formation is also known as primary hemostasis. • Secondary hemostasis, on the other hand, deals with converting fibrinogen into fibrin via the coagulation cascade to form a strong plug to stop bleeding. • Too little coagulation and you'll bleed. Too much coagulation and you will thrombose. Both extremes are bad. • Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis). • Platelets are called thrombocytes cells of thrombus . • The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside. • When platelets roll over the smooth endothelium, nothing happens. • But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis). • Then, the coagulation factors are stimulated thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis). • After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow. • Hemostasis is defined as “cessation of blood bleeding”. • There are 2 types of hemostasis: • 1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets). • 2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors). • Get all of my notes and cases here: / medicosis • Check my full playlist on bleeding and coagulation here: https://goo.gl/Dt41Bg • ► If you love MNEMONICS, check out this amazing website https://www.picmonic.com/referrals/JK... • ► If you need some flashcards to memorize better, try firecracker: https://mbsy.co/gcHHP They have many flashcards that appear in your feed based on how well you remember the answer…Check them out…They are really good. • *** As a small gift for my viewers, here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0 Learning has never been easier. • *** Also, try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2 • Books that I use for this series: • ► Guyton and Hall Medical Physiology Textbook https://goo.gl/yZoeS9 • ► Goljan Rapid Review Pathology, https://amzn.to/2MufTPw • ► Harrison’s Internal Medicine https://amzn.to/2OJiVNf • ► Goldman-Cecil Medicine https://amzn.to/2N0v93u • ► Davidson’s Principles and Practice of Medicine https://amzn.to/2vTmf1p • • To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. 1ry hemostasis involves platelets and 2ry hemostasis involves the coagulation cascade. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/ • ► Visit my website: https://www.medicosisperfectionalis.com/ My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/ 📱Save on your mobile phone bill: http://fbuy.me/q6bMj 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/...

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