GraftversusHost Disease Advances in Prevention and Treatment

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=BdgCwimOsE0

Summary: Several new therapies have recently been approved to prevent and treat graft-versus-host disease (GVHD) and more are being studied. The new therapies are more effective than the standard GVHD therapies and should result in a lower incidence of GVHD with fewer toxicities for patients, going forward. • Presenter: Marcello Rotta MD, Colorado Blood Cancer Institute, part of the Sarah Cannon Cancer Institute at Presbyterian/St. Luke's Medical Center • To read the transcript, go to: • https://www.bmtinfonet.org/video/graf... • Highlights: • A new, effective strategy to prevent GVHD after a transplant using donor cells (an allogeneic transplant) is to give patients post-transplant cyclophosphamide (Cytoxan®). • Three new drugs have proven more effective than traditional treatments for GVHD when it occurs: JAKAFI® (ruxolitinib). IMBRUVICA® (ibrutinib) and REZUROCK® (belumosudil). • Some of the newer therapies to treat GVHD work without suppressing the patient’s immune system or increasing the risk of infection. • April 2023, Part of the Virtual Celebrating a Second Chance at Life Survivorship Symposium • The presentation is 37 minutes long, including 21 minutes of Q A • Key Points: • (01:14): The cells provided by a donor for a patient’s stem cell transplant include the donor’s blood-forming stem cells, as well as the donor’s immune cells. The donor's immune cells can attack the recipient and are responsible for graft-versus-host disease. • (03:16): Acute GVHD generally occurs during the first three months after transplant. Chronic graft-versus-host disease typically occurs later and is the most serious long-term complication of a transplant using donor cells (allogeneic transplant). • (08:02): Post-transplant cyclophosphamide (Cytoxan®) is a new treatment that can prevent graft-versus-host disease in more patients than drugs traditionally used. • (13:55): A second to way reduce the incidence of GVHD is to remove the T-cells that cause GVHD from the donor's cells, before giving them to the patient. • (16:09): A promising strategy, called Orca-T, is being studied to reduce the incidence of GVHD while preserving the anti-leukemia effect of the donor cells.. • (20:33): Once GVHD occurs, the standard treatment has been steroids, which are successful for only half of patients and can cause serious side effects. • ((23:24): IMBRUVICA® (ibrutinib) is an effective treatment for some patients with chronic GVHD, particularly those with very tight or sclerotic skin. • (25:57): JAKAFI® (ruxolitinib) is effective against both acute and chronic graft-versus-host disease, and does not suppress the patient’s immune system. • (29:41): In studies of REZUROCK® (belumosudil), 77% of people with chronic GVHD showed improvement. It also does not suppress the patient’s immune system. • (33:40): Axalitimab is a new drug being studied to block macrophages that also contribute to chronic graft-versus-host disease. The drug is well tolerated, and ongoing clinical trials will determine its effectiveness. • Meet the speaker: https://bloodcancerinstitute.com/phys... • WHO WE ARE: BMT InfoNet is dedicated to providing patients and their loved ones with emotional support and high quality, easy-to-understand information about blood stem cell transplants (bone marrow, peripheral blood and cord blood) and other cellular therapies. Whether you are just beginning your transplant or cellular therapy journey, or learning to manage the joys and challenges of survivorship, • BMT InfoNet is here to help before, during and after treatment. Our goal is to empower you with credible information and emotional support, so that you can take a more active role in decisions affecting your health. http://www.bmtinfonet.org • VISIT US ON SOCIAL MEDIA: • • / bmtinfonet • / bonemarrowstemcelltransplantclub • / bmtinfonet • • / bmtinfonet • / bmt-infonet

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