How the exonintron junction is introduced into the spliceosomes active site
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=Y8oCJEJo360
The process of reading the genetic code of DNA to produce proteins involves an intermediate molecule called messenger RNA (mRNA). Initially mRNA contains sequences that won’t form part of the new protein, termed introns, as well as protein-coding sequences known as exons. Removal of introns and joining together of exons is called splicing and is performed by the spliceosome, a large molecular machine in eukaryotes that plays an essential role in the control of gene expression. The junctions between exons and introns, known as splice sites, must be very precisely recognised, since mistakes in producing mature mRNA can lead to disease. • A new study from Kiyoshi Nagai’s group in the LMB’s Structural Studies Division has identified the previously unknown mechanism by which the splice site at the start of an intron is brought to the active site of the human spliceosome, allowing the reaction to begin. • This movie presents how the 5’ splice site is delivered to the spliceosome by the U1 snRNP, transferred to the U6 snRNA through the action of Prp28, and how this transfer triggers an important remodelling in the spliceosome, which ultimately leads to the formation of its active site. • Read the full story here: • https://www2.mrc-lmb.cam.ac.uk/snapsh... • You can find more videos highlighting research being done in our Structural Studies Division here: • • Structural Studies Division • Another playlist you might be interested in: • Electron cryo-microscopy - • Electron Cryo-Microscopy • -- • About the MRC Laboratory of Molecular Biology (LMB): • The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. • More links: • Official Site: https://www2.mrc-lmb.cam.ac.uk/ • Facebook: / mrc.lmb • Twitter: / mrc_lmb • Instagram: / lmbnews • LinkedIn: / mrc-laboratory-of-molecular-biology • Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...
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