Dr Dominic DAgostino Epigenetic Effects of Ketone Bodies

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=amck3X1qZgU

Dr. Dominic D'Agostino • Associate Professor (with tenure) at the University of South Florida • Senior Researcher at the Institute of Human Machine Cognition • The primary focus of our laboratory is developing and testing metabolic-based therapies, including ketogenic diets, ketone esters, ketone supplements and metabolic-based drugs. Our research also explores the use of these metabolic therapies for a broad range of disorders linked pathophysiologically to metabolic dysregulation, including seizures, neurological disorders, wound healing, muscle wasting and cancer. Our laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies. This research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. • β-hydroxybutyrate: much more than a metabolite • Abstract • The ketone body β-hydroxybutyrate (βOHB) is a convenient carrier of energy from adipocytes to peripheral tissues during fasting or exercise. However, βOHB is more than just a metabolite, having important cellular signaling roles as well. βOHB is an endogenous inhibitor of histone deacetylases (HDACs) and a ligand for at least two cell surface receptors. In addition, the downstream products of βOHB metabolism including acetyl-CoA, succinyl-CoA, and NAD+ (nicotinamide adenine dinucleotide) themselves have signaling activities. These regulatory functions of βOHB serve to link the outside environment to cellular function and gene expression, and have important implications for the pathogenesis and treatment of metabolic diseases including type 2 diabetes. • https://www.ncbi.nlm.nih.gov/pubmed/2...

#############################

New on site