RNA Splicing by the Spliceosome Supplemental Video 4 Spliceosome activation

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=dIrwW9UeHm8

A supplemental video from the 2020 review by Max E. Wilkinson, Clément Charenton, and Kiyoshi Nagai, RNA Splicing by the Spliceosome, from the Annual Review of Biochemistry: https://www.annualreviews.org/doi/10.... • Shown: Spliceosome activation, showing transition from B complex to Bact complex and formation of the active site. This shows how U6 snRNA is freed from its U4 snRNA chaperone by Brr2 helicase, allowing U6 to form the active site. A huge number of proteins dissociate and associate at this stage. Structures derive from PDB codes 6AHD for human B complex and 5Z56 for human Bact complex, with other structures informing the transition. U4/U6 di-snRNP proteins are shown departing before Brr2 action on the U4/U6 duplex but these events may coincide. • Read more about Kiyoshi Nagai's life and spliceosome research here: • https://www2.mrc-lmb.cam.ac.uk/kiyosh... • You can find more videos about RNA splicing and the spliceosome here: • • RNA Splicing by the Spliceosome • Another playlist you might be interested in: • Research Highlights in our Structural Studies Division - • Structural Studies Division • -- • About the MRC Laboratory of Molecular Biology (LMB): • The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. • More links: • Official Site: https://www2.mrc-lmb.cam.ac.uk/ • Facebook: / mrc.lmb • Twitter: / mrc_lmb • Instagram: / lmbnews • LinkedIn: / mrc-laboratory-of-molecular-biology • Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...

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