mTOR Inhibitors Human Trials Reversal Of Aged Immune System

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mTOR inhibition with rapamycin has shown promising life extending results in animal models (Harrison et al., 2009). • Rapamycin has been used in the clinic as an immunosuppressant for kidney transplant and the side effect profile is relatively well studied in this patient population (Li et al., 2014). However, mTOR inhibitors such as rapamycin has also been tested in healthy elderly with little to no side effects reported after up to 8)weeks of treatment (Kraig et al., 2018; Mannick et al., 2018). • A main concern inhibiting mTOR in the elderly is the possibility of immune suppression. However, six-week treatment with an mTOR inhibitor revealed promising results in 264 elderly individuals (Mannick et al., 2018). Whole blood mRNA sequencing analysis showed that genes involved in anti-viral immune response were upregulated significantly in the treatment group, and infections rates were reduced significantly compared to placebo treatment. No significant effects on inflammatory markers were observed as IL-6, interferon-gamma, TNF-α, and IL-18 concentrations remained unchanged. • Furthermore, the immune response to an influenza vaccine showed significant improvements in the treatment group as hemagglutination inhibition tests showed increased anti-viral antibody response. The results indicate that TORC1 inhibition improves systemic immune function in the elderly with decreased infection rates and upregulated immune function perhaps due to an augmentation of interferon mediated viral defences (Mannick et al., 2018). • Dr Joan Mannick presents about the potential positive impact of Rapamycin and Rapalogs in both animal and human in this presentation. • =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= • https://iherb.co/gTEamWK • iHerb All Supplements Health Products Discount Link • New Customer 10% off, existed customer 5% off • =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= • Please note that the links above are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support! • ___________________________________________ • DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. • • #mTOR #Rapamycin #rapalog #healthspan #longevity #epigenome #epigenetic #DavidSinclair #NMN #sirtuin #NadBooster #Exercise #NAD #NMN #Rejuvenate #Reprogramming #Mitochondria #ALA #Metformin #PQQ #CoQ10 #Carnitine #Antioxidant #LookYounger #NMN #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #aging #Lifespan #NMN #NR #Spermidine #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Sirtuins #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome

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