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USMLE STEP 2 Question of the Day 15
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Subscribe for daily Step 2 questions and more medical education content! • Correct Answer: A. Autosomal Dominant • Topic: Neuro • Explanation: • A. Autosomal Dominant • Correct Answer: Peutz-Jeghers syndrome (PJS) is inherited in an autosomal dominant pattern. This means that only one copy of the altered gene (in this case, the STK11 gene) is sufficient to cause the disorder. Individuals with PJS have a 50% chance of passing the altered gene to their offspring, regardless of the gender of the parent or the child. • Other Answer Choices: • B. Autosomal Recessive • Explanation: Autosomal recessive inheritance requires two copies of the altered gene, one from each parent, for the disorder to be expressed. Peutz-Jeghers syndrome does not follow this pattern; it can manifest with just one copy of the mutated STK11 gene. • C. X-Linked Recessive • Explanation: X-linked recessive inheritance involves mutations on the X chromosome. Males are typically more affected because they have only one X chromosome. Peutz-Jeghers syndrome is not linked to the X chromosome and affects both males and females equally, as it is associated with a mutation on an autosome (chromosome 19). • D. Imprinting Disorder • Explanation: Imprinting disorders involve genes that are expressed in a parent-of-origin-specific manner. This means that the disease manifests depending on whether the mutated gene is inherited from the mother or the father. Peutz-Jeghers syndrome is not an imprinting disorder; its inheritance is straightforward autosomal dominant, without parent-specific expression patterns. • Summary • Peutz-Jeghers syndrome is inherited in an autosomal dominant pattern, making option A the correct answer. This means that a mutation in only one of the two copies of the STK11 gene is sufficient to cause the disorder. • • • Tags: #usmlestudents #usmle #step1 #step1prep #step2 #nbme #usmleprep #usmlepreparation #usmlestep1review #usmlestep #usmleexams #med #meded #medicalschool #medicaleducation #medicalexam #medical #medicalstudent #questionoftheday #qotd #qbank #freestepstudying #viralreels #viralshorts #viralshortvideo
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